The correct answers to this question would be alternatives B)"Florence." and D)"Milan.".
The Renaissance was a period in time that saw great advancements in several areas of science. It was an era of enlightenment, curiosity, and paved the way for many ideas such as humanism. It was vital for the development of the world we see today.
It spread in Europe, especially in Italy, that's why the provinces of Milan and Florence could be mentioned in order to answer this question.