Final answer:
The neurologic drugs that have an effect on GABA among the options given are clonazepam and lorazepam, which are benzodiazepines. These medications enhance the inhibitory effect of GABA by acting on GABA receptors in the central nervous system.
Step-by-step explanation:
The question pertains to which neurologic drugs affect the neurotransmitter gamma-Aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter in the central nervous system (CNS), and it plays a crucial role in reducing neuronal excitability throughout the nervous system. Drugs that enhance GABA's effect, known as GABA agonists, have a quieting effect on the brain due to their promotion of GABA receptor activity. Among the listed options, the correct ones are clonazepam and lorazepam. Both of these medications are benzodiazepines, which are known to work by enhancing the effects of GABA at the GABAA receptor, resulting in increased inhibition of neural activity.
Other drugs such as zolpidem also act on GABA receptors but are not listed with a correct pairing in the question. Pregabalin and gabapentin are drugs that affect the GABAergic system but not through direct action on GABA receptors - instead, they modulate the release of GABA. Neostigmine, on the other hand, acts on cholinergic receptors and thereby does not have a direct effect on GABA activity. Amitriptyline is an antidepressant that primarily affects serotonin and norepinephrine reuptake and has negligible effects on GABA neurotransmission.