Question

Using the chart, which of the following point mutations will cause the most harmful effect on an individual?

A. The sequence reads AUU; a change in the second base from U to C
B. The sequence reads CGA; a change in the first base from C to A
C. The sequence reads UGU; a change in the third base from U to A
D. The sequence reads UUA; a change in the first base from U to C and a change in the third base from A to G

Answer 1

The right answer is C. (non sens mutation are the most harmful)

In genetics, a nonsense mutation is a point mutation in which a nucleotide of a codon is changed, inducing the replacement of a codon encoding an amino acid (UGU, cystein) by a stop codon (UGA). The resulting protein, truncated and therefore incomplete (because the translation ends prematurely, and therefore we will have a truncated protein), is generally non-functional.

Answer 2

"The sequence reads UGU; a change in the third base from U to A" is the one point mutation among the following choices given in the question that will cause the most harmful effect on an individual. The correct option among all the options that are given in the question is the third option or option "C". I hope that the answer has helped you.