Answer:
Option (3).
Step-by-step explanation:
Enzymes are the bio catalyst that can increase the rate of a bio chemical reaction without themselves going under any change. Enzyme decreases the activation energy of the reaction and increases the rate of reaction.
Denaturation of protein results in the loss of biological activity of enzyme. The enzyme loses its shape and cannot catalyze the reactions as enzymes are shape specific.
Thus, the correct answer is option (3).