Long-term overconsumption of alcohol causes death of brain cells, which can lead to brain disorders as well as a lowered level of mental or physical function.
Liver damage from alcohol can result in cirrhosis, a severe medical condition that can require a liver transplant to treat.
Long-term overconsumption of alcohol can cause pancreatitis, a very dangerous inflammation of the pancreas, and it can also cause nerve damage.
Tolerance, a long-term effect of alcohol in which the body becomes accustomed to higher and higher doses of alcohol after a long period of overconsumption. This makes it possible for long-term drinkers to consume amounts of alcohol that are dangerous without experiencing short-term effects that might otherwise convince them to stop. Tolerance can lead to dependence and then to addiction or alcoholism in some individuals