A karyotype is a sorted preparation of the chromosomes of an organism.
In this case, we have a normal human karyotype, with 22 pairs of autosomal chromosomes and a pair of sex chromosomes.
All pairs have two chromosomes, so the individual doesn't have Down's Syndrome, and the chromosomes of the sex pair are different, which means the individual is a male.
This means the right answer is B. They are male.