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In the sixteenth century, what affected venice?

User AsTeR
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Italian turmoil of the early 16th century, Venice enters a long and gradual period of decline.
User Another Ordinary
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Answer:

The long invasion of Italy by the French and Spanish armies affected Venice in the 16th century; Venice was also affected by The League of Cambrai (an alliance of European powers including the Vatican, France, Spain, Germany and England all against the Venetian Republic), after these conflicts, Venice had severe losses but they retrieved all their mainland territories later on.

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User Jameswelle
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