The cytoplasm is the intracellular space between the plasma membrane and the nuclear envelope in eukaryotes, while in prokaryotes it corresponds to the entire intracellular area. The cytoplasm is filled with a colloidal and semi-fluid matter called cytosol, in which the cell organelles are suspended. In eukaryotes, as opposed to protoplasm, the cytoplasm does not include the cell nucleus, whose interior is formed by nucleoplasm. In general, the cytoplasm is everything that comprises the cell minus the nucleus and plasma membrane.
The movement of calcium ions into and out of the cytoplasm is considered to be a signal for the activity of metabolic processes.