Question

Which of the following is false about acetyl-CoA?a. It is central in metabolism.b. It is generated from the acetyl group of oxaloacetate.c. It can donate acetate to fatty acid, ketone body, and cholesterol synthesis.d. It can easily donate acetate based on its "high energy" thioester linkage.e. It feeds into the CAC where it is ultimately converted to carbon dioxide.

Answer 1

Acetyl-CoA, or acetyl coenzyme A, takes part in many metabolic reactions, including the metabolism of proteins, carbohydrates, and lipids (A is true), this is .

Is particularly important in the Krebs cycle, where the acetyl group oxidizes for energy production (E is true).

Acetyl-Co A can be synthesized in several ways:

• Citrate produced in the glycolysis gives place to acetyl-CoA and oxaloacetate.

,

• CoA gets an acetate added by the acetyl-CoA synthetase

,

• The alcohol dehydrogenase acetylates CoA using ethanol

,

• The degradation of ketogenic amino acids can be converted into acetyl-Coa and acetoacetate.

,

• Pyruvate from glycolysis loses a carboxyl group and form acetyl Co-A

,

• The beta-oxidation of fatty acids produces acetyl-CoA as a byproduct.

This means B is false

Acetyl-CoA also has an important role in the synthesis of cholesterol, fatty acids, and ketone bodies. (C is true)