Final answer:
The measurement 100.5L has four significant digits, as non-zero digits and zeros between non-zero digits are considered significant.
Step-by-step explanation:
The student has asked to determine the number of significant digits in the measurement 100.5L. According to the rules of significant figures, all non-zero digits are significant. Therefore, '1', '0', '0', and '5' are significant. Importantly, any zeros located between non-zero digits are significant as well. Additionally, the final zero after the decimal point indicates that a precise measurement was made to the tenths place, so it is counted as significant. Thus, the number 100.5L has four significant digits.