Question

Sickle-cell anemia is caused when a mutation results in the replacement of glutamate with valine. Which type of mutation is observed here?

a.chromosomal mutation
b.frameshift mutation
c.substitution mutation

Answer 1

The correct answer is C. Substitution mutation

Substitution mutations are single nucleotide changes in a DNA codon. A codon is a three nucleotide code that gives an information for a specific amino-acid. In this case,the codon was changed from the codon for a valine to a codon for glutamate. This causes a change in the peptide chain that forms the protein.

Answer 2

Out of the following choices, the type of mutation observed is substitution mutation. The correct answer is C.