Perform the operation in the choices to determine the coefficients of the terms.
(Addition) -4x - 1 + 2x + 4 = -2x + 3
(Subtraction) -4x - 1 - (2x + 4) = -6x - 5
(Multiplication) (-4x - 1)(2x + 4) = -8x² -18x -4
Thus, the answer is multiplication as it gives a numerical coefficient equal to -18.