The correct answer is C) the spread of European disease to Africans with little immunity.
One of the most negative impacts on Africans that arose from European colonialism during the 15th to 18th centuries was the spread of European disease to Africans with little immunity.
European people spread many diseases in the African colonies. Native Africans tribe were clean and healthy. So when the European conquerors arrived in Africa, their hygiene habits were so much different to the African people. Furthermore, those diseases did not exist in the African continent and Africans had no immunity at all to those unknown diseases. The contagious diseases resulted in thousands and thousands of people killed. Something similar happened in South America, where many Native South American tribes disappeared due to diseases that Spanish people had such as smallpox, cholera, influenza, and measles.