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Sulfur oxides Carbon monoxides Chlorofluorocarbons (CFCs)Nitrates are responsible for the hole in the ozone layer.

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The best answer for the question above would be the chloroflourocarbons or the CFCs. These chloroflourocarbons or CFCs are the ones responsible for the depletion of the ozone - which leads to leaving a hole in its layer. These gases eat out the ozone layer and allows harmful UV rays of the sun to come in the Earth.
User Denis Khvorostin
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