The type of mutation that is more likely to result in a non-functional protein is a frameshift mutation.
The following are some of the evidences why it will result to a non-functional protein:
1. When these mutations happens, it can lead to a modification of the reading frame that entirely change the sequence of the amino acid.
2. It can also result to a defective protein product with an amino acid that is improperly sequenced. The resulting protein will be entirely new or cannot be used.
3. Stop codon is also a result of a Frameshift mutation.
Reason:
This type of mutation is present when there is an insertion or deletion of nucleotide bases. These mutation shifts the grouping and modifies the code of amino acids. The resulting protein will be non-functional.