The correct answer is C, to explain a specific statement. A is incorrect because commas can be used to convey contrast.
His shirt was red, while his pants were blue.
B is incorrect because 'yes' and 'no' are technically interjections, so they can be separated from the rest of a sentence by a comma.
Yes, that is the correct answer.
D is incorrect because, as mentioned above, interjections are often separated from the rest of the sentence by a comma or an exclamation mark.
Oh, I see.
Hope this helps!