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Down’s syndrome results from people having an extra copy of chromosome 21 in their cells as shown here. People with Down’s syndrome have both a lower IQ and a shorter life expectancy than those without Down’s syndrome. This is an example of

User Jdgray
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D) changes in chromosomes leading to changes in cell processes.

User Leron
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The answer is trisomy 21.

Trisomy 21 is a condition in which an extra copy of chromosome 21 is present. Instead of two chromosomes 21 in a cell, there are three chromosomes. This is a consequence of a failure of chromosome 21 to separate during the gamete development. Thus, an egg cell or a sperm cell will have two instead of one chromosome 21 and after a cross with normal gamete cell, a zygote will have three chromosomes 21.
User Sune Rievers
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