Honestly, when everybody was expanding, they didn't bother with the Native Americans at first. They, the Americans, would march through their territories and instantly claim it as their own. If the Native Americans choose to fight back, then there would be a battle of dominance. After a while, Andrew Jackson decided to expand to his very own liking, but he would move all of the Native Americans into one spot. The Indian Removal Act was signed into law by Jackson in 1830. Great pressure was put on Native American leaders to sign these Removal Acts. The Removal Act was sort of emigrating tens of thousands of Indians to the West. The Trail of Tears was the forced march of the Cherokee's removal which resulted in 4,000 deceased Cherokee. In 1837, Jackson had removed 46,000 Native American people from their land near the Mississipi river and moved them all elsewhere. If it was not during this time period, and more or less Manifest Destiny specifically, Americans would either battle the Native Americans away, or resort back to earlier forces; The Indian Removal Act.