Answer & explanation:
Viruses are basically composed of nucleic acids (RNA, DNA, or both) while prions have no genetic charge, and are basically protein molecules with infecting properties.
Viruses are obligate parasites, in other words, they can only survive by infecting and controlling the cell self-reproducing machinery of the host cell. Viruses that infect prokaryotes (belonging to the bacteria and archaea kingdoms) are called bacteriophages.
In many cases, viruses modify the metabolism of the parasitized cell, which can cause its degeneration and death.
Prion infections, in turn, can be caused by eating contaminated meat, applying hormones or using contaminated surgical instruments.
Prions are able to alter the shape of other healthy proteins, causing prionic behavior in them, and can cause diseases such as spongiform encephalopathy, which gives the brain a spongy appearance.
In addition, prions are resistant to digestive enzymes, heat and even ultraviolet radiation, factors that often degrade proteins and nucleic acids.