To find the area of the shaded region, we can find the area of the rectangle, and subtract the area of the circle (the non shaded part of the rectangle).
Area of Rectangle:
A= 21in x 16in = 336in^2
Area of Circle:
A = pi * r^2
A = 3.14 * (8in)^2
A = 3.14 * 64in^2
A = 201in^2
Subtracting the non shaded region from the area of the rectangle:
336in^2 - 201in^2 = 135in^2
Therefore, the answer is 1. 135in^2