Final answer:
To keep glycolysis going and produce ATP anaerobically, cells must convert NADH back to NAD+ by a process such as lactic acid fermentation. The correct answer to the student's question is D. NADH to NAD+.
Step-by-step explanation:
For glycolysis to produce ATP when no oxygen is present, it is necessary for cells to convert NADH to NAD+. This is because during glycolysis, NAD+ acts as an electron carrier and is reduced to NADH. The process of reducing NAD+ to NADH is essential for the continuation of glycolysis. Without the regeneration of NAD+, glycolysis would halt because there would be no NAD+ to accept electrons during the conversion of glyceraldehyde 3-phosphate (GAP) to 1,3-bisphosphoglycerate (1,3 bPG).
In the absence of oxygen, cells typically convert pyruvate to lactate via lactic acid fermentation. This reaction also regenerates NAD+ from NADH, allowing glycolysis to continue and produce ATP. The correct answer is D. NADH to NAD+, which is critical for maintaining the glycolytic pathway when oxygen is unavailable.