First we have to find midpoint of R and S.
We can use formula such for it.

and

.
We obtained coordinates of point Q

and

Now, we can find the line equation using formula y=ax+b.
We can substitute coordinates of P and Q to this formula and solving system of equation get the answer.
After substituting we obtaind such system

From the system of equation we obtain result
Now we can put our resuts to general line equation.
