As given by the question
There are given that the inside edge is 4 in.
Now,
Since sphere fits snugly inside a cube therefore diameter of sphere will be equal to side of the cube
So,
Then,
Volume of the sphere is given by:
And,
The volume of a cube is:
Then,
The volume of the space between the sphere and cube = 64-33.5 = 30.5.
Hence, the answer is 30.5 cube inches.