Insertion
Genetic stability maintenance requires an extremely accurate mechanism for DNA replication and mechanisms for fixing the several accidental lesions that occur continually in DNA. Spontaneous changes in DNA are temporary due to immediate correction process called DNA repair. DNA repair’s importance is very evident from the huge investment that cells form in DNA repair enzymes. In 1000 accidental base changes in DNA , fewer than one results in a permanent mutation due to the efficient elimination by the DNA repair.