Answer: The issue of choosing a caliph
Explanation: The issue that divided Muslims shortly after Muhammad's death was who will succeed Muhammad, i.e. who will be the caliph. Sunni had the thought that anyone is capable enough and qualified can be religious leader - caliph, so it does not have to be from Muhammad's family. Shiite thought that the caliph could only be Muhammad's cousin, following the principle of royal inheritance.