Use P.E.M.D.A.S
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Solve parenthesis first
-59 + 45 = -14
Just think of subtraction 45 - 59 = -14
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-44 + 37 = -7
Again think of subtraction 37 - 44 = -7
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When you subtract a negative from a negative it's always a negative, just think of 14 + 7 = 21 but now you add the negative symbols -14 + -7 = -21
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Your answer is -21