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The skin MAINLY protects the body against infection by

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The skin covers the whole body and protects it from physical damage, microbe infection and dehydration. It is difficult for microbes to penetrate the skin's dry, dead outer cells. In addition the sebaceous glands produce oils which also help to kill microbes.
User Buhtz
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The skin MAINLY protects the body against infection by

serving as a barrier.

User Shrikant Havale
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