Final answer:
The early 1800s saw significant tensions between the U.S. and Great Britain, primarily due to British interference with American trade, impressment of sailors, and support for Native American resistance against U.S. expansion.
Step-by-step explanation:
One of the main issues between the United States and Great Britain in the early 1800s was British interference with U.S. trade and settlement. The tension arose partially due to the French Revolutionary Wars, as the U.S. strove to remain neutral while preserving its right to trade with Europe. The British blockade of the continent affected American merchants, and the practice of impressment, where American sailors were forced into the British Navy, further exacerbated relations. Additionally, the British in Canada supported Native American resistance against U.S. expansion in the Great Lakes area. Diplomatic efforts to resolve these disputes included the dispatching of John Jay to negotiate what became known as Jay's Treaty.