Difference mean subtract 25 4/9 - 12/16
If your question is another thing then
The difference of 25 4/9 and 12/16 is
25 4/9 is mixed number
12/16 is fraction number
You want the answer is decimal is
25 4/9 = keep 25 and take 4 divide by 9 and add 25
25+ 0.44= 25.44
12/16 you need to simplify 12/16 divide by 4= 3/4 = 0.75