The question is asking for the product of these two terms.
First you need to consider the sign, remember the following rules:
positive * positive = positive
negative * negative = negative
positive * negative = negative
negative * positive = negative
In the question, we have a negative term and a positive term, therefore, the answer would be negative.
Now considering the two numbers: 4*4 = 16
Based on the above and taking the sign into consideration, the answer would be as follows:
(-4)(4) = -16