Answer:
In 1821, the opening of the santa fe trail between santa fe and __________ led to a reorientation of new mexico's commerce from the rest of mexico to the united states.
Step-by-step explanation:
The Santa Fe Trail was opened in 1821, was a famous route of transport of the XIX century that ran through the center of North America, connecting the cities of Independence (now Missouri) and Santa Fe (today New Mexico).
The answer is: Missouri.