Final answer:
Renal uremia is the toxic condition caused by the retention of nitrogenous substances such as urea in the blood, often due to kidney malfunctions.
Step-by-step explanation:
The toxic condition characterized by the retention of nitrogenous substances in the blood is called renal uremia. Nitrogenous wastes are generated from the breakdown of proteins, and during normal metabolism, amino acids are deaminated, resulting in the production of ammonia, which is rapidly converted into urea in the liver. Urea is the primary nitrogenous waste in humans and is less toxic. For aquatic and terrestrial animals, there are different methods of nitrogen waste excretion to avoid toxicity; aquatic animals being ammonotelic and mammals being ureotelic. When the kidneys are unable to properly filter these wastes, it leads to a condition known as renal uremia, where there is an abnormal rise in blood urea levels.