The correct answer is D) over-production led to the soil becoming depleted of nutrients.
The biggest negative side effect of Georgia's production of cotton in the 1800s was the over-production led to the soil becoming depleted of nutrients.
Since the 1800’s the most important factor in Georgia's agricultural economy was cotton. In that time, Georgia imported Sea Island cotton from the West Indies. The good thing about the Sea Island cotton is that it produced a long, strong fiber, easily separated from the seed. The bad thing was that Sea Island cotton could be grown only on the coast, where the harvest took longer. But with the removal of Indians and the invention and perfection of the harvest techniques, George became a great producer of cotton until the over-production led to the soil becoming depleted of nutrients.