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What type of mutation is likely to cause the most dramatic phenotypic change?

What type of mutation is likely to cause the most dramatic phenotypic change?
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What type of mutation is likely to cause the most dramatic phenotypic change?

User Shahir Ansari
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No choices? Okay! Hmmm, I would assume it would have to be Nonsense mutation. 
User Eigenchris
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a single nucleotide deletion in an exon coding for an active site
User Mircea Dragota
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