The answer is D. To see why, forget about equations with variables and just look at some numbers:
3 < 5
That's obviously correct, right? Now multiply both sides by -2:
3 * -2 < 5 * -2
-6 < -10
That's not right, and you need to flip the < to > to make it right:
-6 > -10
The same thing applies to division.