This would be translated to:
What time is it?
It is 1:45 PM.
This is because:
Que Hora Es
Que translates directly to what, hora, time, es, is.
What time is it? is the translation.
Son las once y cuarenta y cinco de la noche.
Son translates to It, las is basically is, once is one, y cuarenta, is and forty, y cinco, and five, de la noche, in the night.
So basically, It is one and forty and five in the night, or It is 1:45 in the night.