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The reduction in the body's response to a drug which may accompany drug use is called

User Davecz
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I'm pretty sure this would be a tolerance or drug tolerance. This is when your body doesn't react as much when you use a drug because you have used it before and your body is kind of used to it, so it has less of an effect. Hope this helps!
User Gianluca
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The reduction in the body's response to a drug which may accompany drug use is called." tolerance"
User Koxon
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