A cell checkpoint is a part of the cell cycle of a eukaryotic cell. The cell consider hints coming from inside and outside of the cell and choose whether to go with a division or not. In cancer, cells have abnormal cell cycle checkpoints. These checkpoints aid to carry responses of the immune system to be capable or kill cancer cells. If there is a blockage on these checkpoints, the T-cells can destroy the cancer cells exceedingly. These cell checkpoint act as blockade to carcinogenesis thereby ensuring arranged breakthrough