The correct answer is C. New Orleans.
Step-by-step explanation
The Mississippi River is an American river that is around 3700km long, it runs through the country from north to south until it flows into the Caribbean Sea. This river originates in the state of Minnesota and flows south through the middle of the country until it reaches Louisiana and passes New Orleans before flowing further into the Caribbean Sea. Indeed, New Orleans located in the southern state of Louisiana is one of the main cities along the Mississipi river. This city was founded in 1718 on the edge of this river and became the largest port city of that river. So, the correct answer is C. New Orleans