Question

A man is heterozygous for sickle cell anemia and homozygous dominant for familial hypercholesterolemia. Knowing that these genes are located on different chromosomes and using the information below, predict his possible sperm.

Answer 1

AB and aB this is correct, I took the quiz!

Answer 2

Since it is heterozygous for sickle cell disease, half of its spermatozoids will carry the mutated allele, and the other half will carry the healthy allele.

Since he is homozygous for familial hypercholesterolemia, all his spermatozoids mutate allele.

So we will have two types of spermatozoids, those who will carry both mutated alleles of both diseases, and those who will carry only the mutated allele giving familial hypercholesterolemia (all his descendence will contract this disease of the birth).

For sickle cell disease: "A" is the normal allele, "a" is the mutated allele.

For familial hypercholesterolemia: "B" is the mutated allele and "b" is the normal allele.

therefore the spermatozoa will have for genotype AB and aB.