Mutated EGFR can lead to cancer (especially lung cancer).
A mutation in EGFR is associated with uncontrolled tumor growth, which can accelerate cancer progression.
Epidermal Growth Factor Receptor (EGFR) receptors are found on the surface of tumor cells and their role is to send a growth signal to the nucleus of the cell. Some lung cancer tumors may contain a mutation in their DNA that affects the EGFR. The tumor is said to be "positive for EGFR mutations".
Tumor cells with EGFR mutations are highly sensitive to cancer treatments called "Targeted Therapies" or "EGFR Tyrosine Kinase Inhibitors".