Final answer:
Separation of compounds requires chemical methods because of the chemical bonds between elements, while mixtures can be separated through physical methods due to the absence of chemical bonding between components.
Step-by-step explanation:
The methods for separating compounds and mixtures differ mainly based on the nature of the materials in question. Compounds have definite compositions with chemical bonds between the elements and can only be separated into their elements using chemical methods such as electrolysis. On the other hand, mixtures are physical blends without chemical bonding. They can be separated into their components using physical methods like filtration, distillation, and crystallization. For example, a heterogeneous mixture like salt mixed with pepper can be separated through simple manual methods like sorting, while a homogeneous mixture (solution) like sugar dissolved in water may require distillation to separate the sugar from the water.