Acrylic On Plaster- Uses a fast-drying, synthetic, water soluble paint that can be used on most surfaces. Made from color pigments and a synthetic plastic binder, acrylic paint looks like oil and can be used in a variety of painting techniques. It is better to clean up Folk-Art paints while they are wet, but dried paint can be cleaned up easily as well. Yes, you can use Folk-Art paint on plaster. However, because plaster is very porous and sometimes dusty, you should to first seal the piece with a clear acrylic matte spray sealer.