Question

When an enzyme is denatured, what happens to the enzyme?

Answer 1

The enzyme is permanently damaged... That is really all I can think of but let me know if this is actually helpful or I am just stupid.

Answer 2

Change the pH and the enzyme stops working. Increasing the temperature to 60°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.