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The main river just west of the appalachian mountains that runs into the mississippi river:

User MEE
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Salutations!

The main river just west of the Appalachian mountains that runs into the Mississippi river: ----

The main river just west of the Appalachian mountains that runs into the Mississippi river: Ohio River. Ohio is the largest tributary by capacity. A tributary is smaller rivers joining into larger rivers.

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User Oguz Bilgic
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