Tobacco and all dangerous substances in cigarettes can cause all these diseases, especially COPD, pancreatic cancer, and wrinkles, while leukemia is a possibility, since the benzene element is a substance present in the cigarettes, and is a direct trigger for myeloid leukemia. Even being tobacco and it's substances, something that causes a lot of addiction, it's surprising that it's not a veto product, such as psychotropic drugs. The lungs, pancreas, teeth, and in general the whole human organism suffers large deteriorations from tobacco smoke and more if't is for years.