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Covalent bonds place constraints on the shapes of biological molecules. as the size and complexity of a biomolecule increases, the chemical focus shifts from covalent bonds to noncovalent interactions. noncovalent interactions dictate the stable, native conformations of large macromolecules and polymers while permitting the flexibility necessary for their biological functions. what characteristics of weak noncovalent interactions enable the assembly, stability, and functions of biomolecules?

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The characteristic of the weak non covalent interactions that enable the assembly, stability and functions of bio molecules is that NON COVALENT INTERACTIONS HAVE LARGE AGGREGATE STRENGTH WHEN MULTIPLE INTERACTION ARE PRESENT.
Although they are considered as weak forces, but when present in large number, non covalent interaction has the capacity to stabilize large polymers using their aggregate strength.
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