Ans: p2 + 2pq + q2 = 1. Explanation The Hardy-Weinberg equation is a mathematical equation that can be used to calculate the genetic variation of a population at equilibrium. To explore the Hardy-Weinberg equation, we can examine a simple genetic locus at which there are two alleles, A and a. The Hardy-Weinberg equation is expressed as: p2 + 2pq + q2 = 1.