Final answer:
Prokaryotes lack a membrane-bound nucleus and membrane-bound organelles, are generally smaller than eukaryotes, and have a single circular chromosome in contrast to the multiple, linear chromosomes of eukaryotes. Prokaryotic cells are less complex, and although they utilize supercoiling for DNA packing, they do not use RNA to store genetic information.
Step-by-step explanation:
In comparison to eukaryotes, prokaryotes do not have a membrane-bound nucleus or other membrane-bound organelles. Instead, their genetic material is contained within a nucleoid. Prokaryotic cells are typically smaller and less complex in terms of their internal structures compared to eukaryotic cells. While eukaryotes have multiple, linear chromosomes and a high degree of compartmentalization which allows for greater regulation of gene expression, prokaryotic cells house their genetic information in a single, circular chromosome. Supercoiling managed by DNA gyrase is present in prokaryotes to pack their chromosomes, whereas eukaryotic chromosomes are wound around histone proteins. Some statements about prokaryotic cells, like their chromosomes being composed of single-stranded DNA or using RNA to store genetic information, are not accurate, as they also use double-stranded DNA for chromosomes and do not use RNA as their primary genetic material.