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Enzymes in the _________ are primarily responsible for the metabolism of a drug.

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Enzymes in the liver cells but are also located in cells throughout the body or also known as Cytochrome P450 (CYP450) are endogenous proteins in individuals that act as drug metabolizing enzymes and also have endogenous enzymatic processes that are also used to make cholesterol, steroids and other important lipids such as prostacyclins and thromboxane A2 (metabolites of arachidonic acid).

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